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I was analyzing maleic and fumaric acids in biological extract using a Cogent Diamond Hydride column. After 10 perfect injections (%RSD of retention times around 0.5), I noticed that the peaks intensity diminished about 10 times, however the peaks still have the same retention time. What happened to the column?

Reference Number: AA-00305 Created: 04/02/2012 01:21 PM Last Updated: 07/25/2016 11:11 AM

Most likely, nothing happened to the column. Your mass spectrometer probably needs some attention. I would clean the ion source and check the nebulizer.


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