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I am using a Cogent TYPE-C™column with LC-MS and solvents containing 10 mM ammonium acetate. I noticed that my source was getting white film on it. At the same time the background noise was very low. Is my column bleeding the packing material?

Reference Number: AA-00304 Created: 04/02/2012 01:15 PM Last Updated: 07/22/2016 04:49 PM

Cogent TYPE-C™ columns including the Cogent Diamond Hydride have a very low background noise even when used with LC-MS and the white film most likely comes from ammonium acetate build up from your mobile phase.
These columns have been proven to be extremely durable and because of the direct silicon-carbon bonds of these phases, bonded phase bleed is almost non-existent.

     For symptoms of packing material loss or bonded phase hydrolysis, click here.

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